module specification

Assessment: Coursework  1(a series of in-class tests) 75% +  Coursework 2 (a presentation) 25% [Pass on aggregate]

This module introduces students to key biochemical concepts to provide a foundation for subsequent study in the Applied Biology, Biomedical Sciences, and Molecular & Pharmaceutical Science subject areas at Level 4.
 

The aim of this module is to give students the necessary background to appreciate the structure and function of the key molecules that cells are made of such as proteins, nucleic acids, lipids and carbohydrates.  An introduction to the principles of cellular energetics and metabolism will be given, and the maintenance of biological pH buffering systems will be discussed. This will provide suitable grounding for the study of life science subjects at level 4.

An introductory study of the structure, properties and distribution of biomolecules: proteins: amino acids; peptide bond; levels of protein structure.  Enzyme function.  Carbohydrates: monosacchrides, sugar derivatives; glycosidic bond; oligo- and polysaccharides.  Lipids: classification of lipids, simple and complex, fatty acids and glycerides.  An introduction to metabolic pathways and the production and utilisation of energy. Catabolism and anabolism will be discussed.  An introduction to biological buffering systems will be covered.

Acquisition of knowledge of the subject matter of this module will be promoted through lectures (43 hours), tutorials (22 hours), Self managed time and private study (235 hours). Lectures are used to introduce the basic concepts required to achieve the learning outcomes.  Tutorial sessions  are either problem-directed or discussion-based, designed to work through, and expand on, material delivered in lectures. Students will be expected to prepare for tutorial sessions by reviewing appropriate material and devoting sometime to problem-solving exercises.

The module is supported by a website on WebLearn which includes a number of electronic learning aids. Students would be expected to use the site for assisted study.

On successful completion of this module the students will be able to:

1. Explain the organic chemistry of biological molecules.
2. Differentiate between the basic 'building blocks' of life; proteins, nucleic acids, carbohydrates and lipids.
3. Describe the principles of cellular energetics and the role of enzymes in metabolism.
4. Clarify the chemistry required to comprehend biological pH buffering systems.
5. Distinguish biological homeostatic conditions and biological buffering systems.
6. Research a topic relevant to the module and present findings to peers.

This module will be summatively assessed using 5 progress tests and a presentation.  There will also be formative assessments for the students to complete on-line.
To pass the module students need to achieve a minimum aggregate mark of 40%.

If a student’s attendance at tutorials falls below 80% on a module, this will result in the student failing the module.  Reassessment opportunities will not be available and instead the module will have to be retaken the following year with attendance and payment of fees. Mitigating circumstances cannot be claimed for missed classes; however Module Leaders will take account of absences that are a consequence of recorded disability or otherwise recorded as 'Authorised Absence' when applying the 80% threshold.

• Karp, G (2010) Cell Biology, Wiley 
• Engel, P (2009) Pain-Free Biochemistry: An Essential Guide for the Health Sciences, Wiley

Plus on-line material; see the WebLearn site for details.