module specification

This module provides an understanding and knowledge of the theory and practice of haematology. Examining the different elements that constitute blood in normal and diseased states, investigating the causes and diagnosis of anaemias, haemoglobinopathies and thalassaemias, haematological malignancy, haemostasis and thrombosis.

Semester: Autumn, Spring, Summer (10 credit)
Required prior Learning: None
Assessment: Quizzes (500 words)(30%), reflective learning log (500 words)(30%), coursework (1000 words)(40%)

None

The aims of this module are aligned with the qualification descriptors within the Quality Assurance Agency’s Framework for Higher Education Qualifications. To provide, through in depth study, knowledge and understanding of the theory and practice of haematology as well as to reinforce analytical, evaluative and communication skills. It will also enable students to research a topical issue and present it at an appropriate level and to reflect on the topics studied and their application in biomedical practice.

This module provides an understanding and knowledge of the theory and practice of haemoglobinopathy screening, diagnosis and ethical issues arising. Aetiology, Epidemiology, Genetics and Pathophysiology of Haemoglobinopathies (focusing on Thalassaemia(Thal) and Sickle Cell (SC)) Counselling, management and treatment considerations. Categorisation of thalassemia’s, correlation of the results of laboratory testing with specific thalassaemias and  haemoglobinopathies. 
Workshop: a) Case review and data analysis, SC and Beta Thal Major, antenatal and newborn screening, Laboratory diagnosis and interpretation exercises, - inexperienced NHS haematology staff and MSc Blood Science students.
OR b) Review of updates to laboratory handbook, Case review and data analysis, SC and Beta Thal Major, antenatal and newborn screening, ethical issues, New technologies (Mass Spectrometry, Capillary electrophoresis, other equipment as appropriate), Case study presentations, Unusual Haemoglobinopathies. – Experienced Haematology Staff.
OR c) Review of Haemoglobinopathies, recent updates, Newborn screening programme outcomes, antenatal and newborn screening, ethical issues, Blood Spot programme, Case study presentation and analysis. – newborn screening staff.

Information pertaining to the subject matter will be presented through an integrated programme of lectures and supporting exercises, together with some use of a problem-based learning approach and the guided use of student-centred learning resources.  Lectures will be used to provide a conceptual framework.  Student centred assignments and will enable students to reinforce and expand their knowledge, and develop subject specific skills and competence.

On successful completion of this module students will be able to:
1. Describe the laboratory processes for haemoglobinopathy screening and diagnosis nature, relate genetic theory to laboratory and clinical practice, including awareness of factors affecting prenatal diagnosis, antenatal/newborn screening processes, risks associated with the sample reagents, or method and other tests indicated by the outcome of the analysis and associated ethical issues. 
2. Understand principles of quality control, quality assurance, failsafe procedures, screening policies and diagnosis of haemoglobinopathies, and critically interpret and evaluate information case studies, reporting and communicating the results
3. Demonstrate through the reflective learning journal that the student has reflected on their own performance as an independent professional learner with a focus on their practice.

The module will be formatively assessed by in-course online quizzes (30%) and two coursework components. A reflective learning log (30%; 1500 words) and a written assignment (40%; 1500 words). Criteria for assessment will include an understanding of the subject matter; an ability, both orally and written, to explain, describe and discuss the work; completeness and conciseness of written reports and essays with emphasis upon critical ability and scientific rigor. To pass the module students need to achieve a minimum aggregate mark of 50%. There is a one day workshop session

Component  Learning outcomes
Quizzes 1
Reflective learning log 1,2
Written assignment  1,2,3

Bains B J. (2006) Haemoglobinopathy Diagnosis 2nd Ed. Blackwell.
Bain B J, Bates I, Laffan, MA, Lewis SM. (2006) Dacie and Lewis Practical Haematology 11th Ed. Churchill Livingstone.
Daniel Y, Henthorn J. (2012) Sickle Cell and Thalassaemia – Handbook for laboratories 3rd Edn. NHS
Okpala I. (2004) Practical Management of Haemoglobinopathies. Wiley-Blackwell
Ryan K, Bain BJ, Worthington D, James J, Plews D, Mason A, Roper D, Rees DC, De La Salle B, Streetly A. (2010) Significant haemoglobinopathies: guidelines for screening and diagnosis.  BJH 149: 1; 35-49.  
Trent RJA. (2006) Diagnosis of Haemoglobiopathies, Clin Biochem Rev. 27:1; 27-38.