module specification

This module provides an understanding and knowledge of the theory and practice of transfusion and transplantation. It addresses the identification of blood groups and antibodies, other hematopoietic cell antigens and their clinical significance, the safe supply of blood and blood products, the principles of stem cell and solid organ transplantation, tissue and bone banking, organ transplantation, prophylaxis and immunotherapy, and quality issues
Semester: Autumn, Spring, Summer (10 credit)
Required prior Learning: None
Assessment: Quizzes (300 words)(30%), reflective learning log (800 words)(30%), coursework (900 words)(40%)

The aims of this module are aligned with the qualification descriptors within the Quality Assurance Agency’s Framework for Higher Education Qualifications. To provide, through in depth study, knowledge and understanding of the theory and practice of transfusion and transplantation science and outline the priciples of blood group and antibody identification and their relation to the provision of blood and blood products. The module will also outline the processes related to the safe supply of blood, blood componenet or other tissues for transplantation and reinforce analytical, evaluative and communication skills. Additionally it will allow students to research a topical issue in depth and present it at an appropriate level and reflect on the topics studied and their application in biomedical practice.

Immunology related to transfusion and transplantation practices, Blood grouping principles and significance, antibody screening, Blood donation, blood components, clinical transfusion, HLA, HPA, HNA and their significance, haemolytic disease, transfusion transmitted infections, Stem cell transplantation, and solid organ transplantation.

 Information pertaining to the subject matter will be presented through an integrated programme of lectures and supporting exercises, together with some use of a problem-based learning approach and the guided use of student-centred learning resources.  Lectures will be used to provide a conceptual framework.  Student centred assignments will enable students to reinforce and expand their knowledge, and develop subject specific skills and competence.

On successful completion of this module students will be able to:
1. Identify the important features of the different blood group systems, haemostasis and be familiar with the procedures involved with the safe use of blood products and relate transfusion theory to laboratory and clinical practice;
2. Develop a working knowledge of the principles and practice of transfusion
Science, discuss indication for the use of blood component therapy and identify and discuss in-depth the clinical aetiology and management of immunohaematological and transplantation disorders;
3. Demonstrate an understanding of blood donation, collection, screening and
Storage and describe the role of biomedical scientists in maintenance of transfusion or transplantation laboratory services.
4. Demonstrate through the reflective learning journal that the student has reflected on their own performance as an independent professional learner.

The module will be formatively assessed by in-course online quizzes  (30%) and two coursework components. A reflective learning log (800 words; 30%) and a written assignment (40%; 900 words). Criteria for assessment will include an understanding of the subject matter; an ability, both orally and written, to explain, describe and discuss the work; completeness and conciseness of written reports and essays with emphasis upon critical ability and scientific rigour. To pass the module students need to achieve a minimum aggregate mark of 50%.

Cant A, Jackson G, Galloway A.  (2007) Practical Hematopoietic Stem Cell Transplantation. Blackwell.
Contreras M. Ed. (2008) ABC of Transfusion 4th Ed. British Medical Journal.
Daniels G, Bromilow I. (2010) Essential Guide to Blood Groups. Blackwell.
Knight R. (2011) Transfusion and Transplantation Science. Oxford University Press.
Lederer SE. (2008) Flesh and Blood: Organ transplant and blood transfusion in 20th century America. Oxford University Press
Lewis SM, Bain B J, Bates I. (2006) Dacie and Lewis Practical Haematology 10th Ed. Churchill Livingstone.
Male D, Brostoff J, Roth D, Roitt I. (2006) Immunology 7th Ed. Mosby.
Murphy MF, Pamphilon DH. (2005) Practical Transfusion Medicine 2nd Ed. Blackwell.
Overfield J, Dawson MM, Hamer A. (2007) Transfusion Science. Sion Publishing Ltd.
Phillips JD, Murray PG, Crocker J. (2006) The Biology of Disease 2nd Ed. Blackwell.