module specification

This module provides an understanding and knowledge of the theory and practice of clinical immunology. It expandes on the mechanisms of the mammalian immune system in defence and evasion of microorganisms, the diagnosis and monitoring of immunological disease or disorders, organ transplantation, prophylaxis and immunotherapy, and immunological techniques

The aims of this module are aligned with the qualification descriptors within the Quality Assurance Agency’s Framework for Higher Education Qualifications.  To provide, through in depth study, knowledge and understanding of the theory and practice of clinical immunology, reinforce analytical, evaluative and communication skills. The module will also enable students to research a topical issue in depth and present it at an appropriate level and reflect on the topics studied and their application in biomedical practice.

Review of the basis of immunity: protective role of the immune system.
Immunological disease, over-activity, immunodeficiency, inappropriate response, allergy, autoimmunity and neoplastic. 
Transplantation immunology; immunosuppressive therapy; experimental systems and immunomodulation therapy. Immunological techniques in research and clinical practice.
Immunotechnology: hybridoma technology; monoclonal antibodies and their biochemical and medical applications; vaccine design and production.

Information pertaining to the subject matter will be presented through an integrated programme of lectures and supporting exercises, together with some use of a problem-based learning approach and the guided use of student-centred learning resources.  Lectures will be used to provide a conceptual framework.  Student centred assignments will enable students to reinforce and expand their knowledge, and develop subject specific skills and competence.

On successful completion of this module students will be able to:
1. Demonstrate an understanding of the processes of microorganism detection by and evasion of the immune system and show an understanding of the consequences of inappropriate responses and malfunctions in the ontogeny of immune response components.
2. Apply critical thinking to the analysis and solve immunological problems and show an appreciation of current and evolving concepts in immunology and developments in immunotechnology, immunotherapy and immunoprophylaxis, in relation to the practice of a biomedical scientist.
3. Demonstrate through the reflective learning journal that the student has reflected on their own performance as an independent professional learner.

The module will be formatively assessed by in-course online quizzes (20%) and two coursework components. A reflective learning log (800 words)(40%) and a written assignment (40%; 1000 words). Criteria for assessment will include an understanding of the subject matter; an ability, both orally and written, to explain, describe and discuss the work; completeness and conciseness of written reports and essays with emphasis upon critical ability and scientific rigour. To pass the module students need to achieve a minimum aggregate mark of 50%.

Abbas AK, Lichtmanm AH, Pillai S. (2011) Cellular and Molecular Immunology 7th Ed. Elsevier.
Alberts et al. (2008) Molecular Biology of the Cell 5th Ed.  Freeman. NY
Lodish et al.  (2008) Molecular Cell Biology 6th Ed.  Freeman. NY
Male DK, Brostoff J, Roth DE, Roitt IM (2012) Immunology 8th Ed. Mosby.
Delves PJ, Martin SJ, Burton DR, Roitt IM (2011) Essential Immunology. 12th Ed. Blackwell
Murphy K. (2011) Janeway's Immunobiology 8th Ed. Garland Science. NY