module specification

BE6056 - Bioinformatics & Molecular Modelling (2024/25)

Module specification Module approved to run in 2024/25
Module title Bioinformatics & Molecular Modelling
Module level Honours (06)
Credit rating for module 15
School School of Human Sciences
Total study hours 150
114 hours Guided independent study
36 hours Scheduled learning & teaching activities
Assessment components
Type Weighting Qualifying mark Description
Coursework 50%   Data Analysis (1500 words)
Coursework 50%   Data Analysis (1500 words)
Running in 2024/25

(Please note that module timeslots are subject to change)
No instances running in the year

Module summary

The module uses online public databases and software to extract, analyse and interpret nucleic acid and protein sequences and to model the structures of RNA and protein sequences. Genomics, in particular, with an emphasis on pharmacogenomics and phylogeny are covered.

The aims of this module are aligned with the qualification descriptors within the Quality Assurance Agency’s, Framework for Higher Education Qualifications. The module aims to provide familiarity with the primary and secondary databases used to analyse DNA, RNA and protein sequence, expression and structure, within and across genomes. Students will be given the opportunity to develop informatics skills for extracting, analysing and presenting data to extract biological knowledge. The principles of macromolecular, and in particular protein structure will be applied to the building of molecular models using modelling and graphics software. Applications of modelling will emphasise the importance of protein-protein interactions and protein-drug interactions. This module aims to provide students with the qualities and transferable skills necessary for employment requiring: the exercise of initiative and personal responsibility; decision-making in complex and unpredictable contexts; and, the learning ability needed to undertake appropriate further training of a professional or equivalent nature.

Prior learning requirements



The primary and secondary databases in biology including protein and gene sequences, protein structures, genome databases, disease databases - content, structure of files, links and other information.
Software for sequence analysis, including screening gene and protein databases, comparison of sequences, identification of functional domains, classification, phylogenetic analysis, RNA structure prediction.
Principles of protein architecture – review the role of non-covalent forces in the formation of secondary, tertiary and quaternary structures; protein folds and domains; folding and stability; membrane proteins; protein movement; protein complexes.
Software for analysis of known protein and nucleic acid structure.
Modelling protein structure; structure prediction by homology modelling; other approaches to prediction; probing active sites; protein interaction with other biomolecules; both proteins and drugs in particular. Protein-protein interactions and systems biology.

Balance of independent study and scheduled teaching activity

Students will be presented with material in interactive teacher-lead activities in the form of lectures, and IT tutorials. Student learning time will be used for class assignments, data analysis and preparation for coursework assignments.

Learning outcomes

On successful completion of this module students will be able to:
1. Critically analyse the type of information contained within different primary and secondary databases and be able to extract appropriate biological information and select appropriate software for informatic analysis and present the output in a useful form with biological context.
2. Evaluate the important factors which determine the structure of, and interactions between, different types of biological molecules.
3. Analyse standalone structures and complexes between different structures utilising graphics and modelling software and critically analyse results obtained from the running of bioinformatics programs