module specification

BM7027 - Bioinformatics and Molecular Modelling (2020/21)

Module specification Module approved to run in 2020/21
Module title Bioinformatics and Molecular Modelling
Module level Masters (07)
Credit rating for module 20
School School of Human Sciences
Total study hours 200
 
44 hours Scheduled learning & teaching activities
120 hours Guided independent study
36 hours Assessment Preparation / Delivery
Assessment components
Type Weighting Qualifying mark Description
Coursework 50%   Data Analysis (1000 words)
Coursework 50%   Practical exercise & report (1000 words)
Running in 2020/21
Period Campus Day Time Module Leader
Autumn semester North Friday Afternoon

Module summary

The module uses online databases and software to extract, analyse and interpret DNA and protein sequences and to model structures of proteins.
This module aims to provide familiarity with the primary databases and common software packages used to analyse DNA, RNA and protein sequence, expression and structure, within and across genomes. It will also develop informatic skills for extracting, analysing and presenting data to extract biological knowledge and students will apply the principles of macromolecular, and in particular protein, structure to the building f molecular models using modelling and graphics software. The module will examine applications of modelling with emphasis on understanding the interactions between proteins and other molecules of biological or synthetic origin.

Syllabus

LO 1 - 3

Primary and secondary databases in areas of biology, genetics, pharmaceutical science and biomedical science including gene and protein sequence databases, 3-D structure databases, genome databases and disease databases.
Application of online servers to sequence alignment and analysis of gene and protein databases, RNA structure prediction, molecular modelling and phylogenetic classification and pharmacogenomics analysis. Docking and drug design.

Balance of independent study and scheduled teaching activity

Students will be presented with material in interactive teacher-led activities in the form of lectures and computer-based tutorial sessions. Student learning time will be used for assignments, data analysis and the preparation of coursework assignments.

Learning outcomes

After completing the module students should have developed:
1. 1. An advanced systematic knowledge of the theoretical aspects of bioinformatics and molecular modelling and an up-to-date knowledge of current developments and knowledge in this area;
2. 2.  An ability to apply knowledge learnt to bioinformatics and molecular modelling problems involving the extraction, analysing and presentation of data as appropriate;
3. Intellectual skills, through reflection and through practice by engagement with the module learning materials.

Assessment strategy

Formative feedback given throughout computer-based tutorial sessions. Summative feedback on returned coursework.

Component                                    Learning outcomes
Data Analysis 1                             1,2
Practical exercise & report            1-3

Bibliography

Key Online Resources:
Primary DNA and Protein Sequence Databases
GenBank: www.ncbi.nlm.nih.gov/Genbank      EMBL:       www.ebi.ac.uk/embl
DDBJ:       www.ddbj.nig.ac.jp                          UniProt:   www.uniprot.org
Protein database at the NCBI: www.ncbi.nlm.nih.gov/protein

Secondary Protein Databases and Sequence Alignment Servers
PROSITE:   www.expasy.ch/prosite                    PRINTS:www.bioinf.manchester.ac.uk/dbbrowser/PRINTS
Pfam:        pfam.sanger.ac.uk                            
SMART:     smart.embl-heidelberg.de
NCBI BLAST and PSI-BLAST:   www.ncbi.nlm.nih.gov/blast                      
BLAST and FASTA@EBI:       www.ebi.ac.uk/Tools/sss/            
Clustal Omega:     www.ebi.ac.uk/Tools/msa/clustalo/
Protein Structure Prediction and Other Important Websites
SWISS-MODEL:  www.expasy.org/swissmod/SWISS-MODEL.html
3D-JIGSAW:        bmm.crick.ac.uk/~populus/
I-TASSER:            zhanglab.ccmb.med.umich.edu/I-TASSER/            
Protein Data Bank:   www.rcsb.org/pdb             PHYRE2:               www.sbg.bio.ic.ac.uk/phyre2
Swiss PDB viewer:     spdbv.vital-it.ch               SwissDock:            www.swissdock.ch

Bromham, L.  (2008) Reading the Story in DNA a beginner’s guide to molecular evolution.  Oxford University Press.
Campbell A.M. and Heyer L.J. (2006) Discovering Genomics, Proteomics and Bioinformatics (2nd Edition) Pearson Benjamin Cummings.
Dardel, F. and Kepes, F. (2006) Bioinformatics: Genomics and post-genomics, Wiley.
Gopal, S., Haake, A., Jones, R.P. and Tymann, P. (2009) Bioinformatics: A Computing Perspective, McGraw-Hill.
Hodgman, C., French, A. and Westhead D.R. (2009) Bioinformatics (Instant Notes) BIOS Scientific Publishers.
Lesk A.M. (2008) Introduction to Bioinformatics (3rd Edition), Oxford University Press.
Lesk A.M. (2010) Introduction to Protein Science: Architecture, Function and Genomics, (2nd Edition) Oxford University Press.
Pevsner, J. (2009) Bioinformatics and Functional Genomics, 2nd Edition, Wiley-Blackwell.
Zvelebil, M. and Baum J.O. (2008) Understanding Bioinformatics, Garland Science.