BM7112 - Introduction to Toxicology (2021/22)
|Module specification||Module approved to run in 2021/22|
|Module title||Introduction to Toxicology|
|Module level||Masters (07)|
|Credit rating for module||10|
|School||School of Human Sciences|
|Total study hours||100|
|Running in 2021/22||
This module provides information and guidance to faciliatate an indepth understanding and knowledge of the theory and practical applications of toxicology. It explains the underlying mechanisms of xenobiotic (drug) metabolism and enables these ideas to be expanded to the understanding of human health and disease.
Prior learning requirements
This module provides an understanding and knowledge of the theory and practice of toxicology
It will include an introductory background to toxicology, scope of subject, central role of drug or xenobiotic metabolism is determining toxicity, methods for establishing levels of toxicity, techniques of measurement including HPLC, GC and coupled mass spectrometric detection. Application of the principles to the understanding of specific toxicities inter alia ethanol, paracetamol, carbon monoxide, ethylene glycol, redox-cycling drugs.
Learning Outcomes LO1 - 5
Balance of independent study and scheduled teaching activity
Information pertaining to the subject matter will be presented through an integrated programme of lectures and supporting exercises, together with some use of a problem-based learning approach and the guided use of student-centred learning resources. Lectures will be used to provide a conceptual framework. Student centred assignments will enable students to reinforce and expand their knowledge, and develop subject specific skills and competence.
On successful completion of this course students will be able to:
1. Have knowledge of the scope of toxicology, in particular the key roles of absorption, distribution, metabolism and excretion as determinants of toxicity.
2. Relate toxicology theory to laboratory, clinical and forensic practice, including awareness of factors affecting sample integrity, sample clean-up procedures and limitations of analysis.
3. Demonstrate understanding of key aspects of toxicology inter alia drug metabolism, free radical biochemistry, tests for toxicity, structure-function relationships and the detection of toxic substances in bulk and in biological matrices.
4. Understand principles of quality control and quality assurance in relation to toxicology and critically interpret and evaluate information from a particular case study.
5. Demonstrate through the reflective learning journal that the student has reflected on their own performance as an independent professional learner.
The module will be formatively assessed by in-course online quizzes and two coursework components. A reflective learning log (1000 words) and a written assignment (1000 words). Criteria for assessment will include an understanding of the subject matter; an ability, both orally and written, to explain, describe and discuss the work; completeness and conciseness of written reports and essays with emphasis upon critical ability and scientific rigour. To pass the module students need to achieve a minimum aggregate mark of 50%. There are no practical sessions.
Component Learning outcomes
Reflective learning log 3,4,5
Written assignment 3,4,5
Hodgson E (2010) A textbook of Modern Toxicology, 4th Ed. Wiley.
Lee B-M Kacew S (2017) Lu’s Basic Toxicology. Taylor and Francis.
Murray L (2015) Toxicology Handbook. Informa
Timbrell JA (2009) Principles of Biochemical Toxicology, 4th Ed. Informa Healthcare.