CY5052 - Synthetic Techniques for Herbal Medicinal Science (2023/24)
|Module approved to run in 2023/24
|Synthetic Techniques for Herbal Medicinal Science
|Credit rating for module
|School of Human Sciences
|Total study hours
|Running in 2023/24(Please note that module timeslots are subject to change)
|No instances running in the year
The aims of this module are aligned with the qualification descriptors within the Quality
Assurance Agency’s, Framework for Higher Education Qualifications.
This module will equip students with experience of a range of synthetic procedures and the purification steps needed to isolate products for testing.
The module aims to introduce students to advanced synthetic and purification techniques including fractional, vacuum and steam distillation, solvent extraction, fractional crystallisation and column chromatography. It also aims to reinforce safe and correct laboratory working practices emphasising the need for Risk Assessment and the importance of COSHH. Students will also learn about the planning and costing of synthetic experimental procedures.
Prior learning requirements
Purification methods in the laboratory: distillation (atmospheric pressure and under vacuum), recrystallisation, sublimation, solvent extraction procedures; selection of method(s) as appropriate to physical/chemical properties for yield optimisation. COSHH and safe laboratory working practices, risk assessment. Laboratory practical skills, data recording and handling, record keeping and report writing, and the effect of executing experimental procedures under GLP and GMP conditions, quality and quantity control, cost, environmental considerations. Experimental planning. Selected practical procedures: reflux under inert atmosphere; azeotropic dehydration, chromatography, spectroscopy; synthesis and purification of organic and organometallic compounds. LO1,LO2,LO3,LO4
Balance of independent study and scheduled teaching activity
Learning and teaching is based on laboratory sessions (32 hours), lectures (8 hours) and tutorials (4 hours). Practical sessions deal with the variety of skills used in practical chemistry, the recording, handling and interpretation of data, and the reporting of scientific information. Depending on the availability of equipment, students will work individually or in pairs. Writing and data handling skills will be enhanced through both the production of students’ ‘real-time’ laboratory records and the fully developed word-processed version of the practical write-up. Pre-laboratory assignments are provided to prepare the students for the various laboratory sessions.
On successful completion of this module the students will be able to:
1. Devise appropriate separation procedures for the purification of an organic reaction product based on consideration of its physical structure and properties;
2. Perform, record, report and interpret the results of specified synthetic and separation procedures;
3. Design a synthetic route to a simple target product;
4. Make an appropriate assessment of chemical and other hazards in a laboratory experiment.
The module will be summatively assessed by means of a single coursework component. The coursework comprises five practical reports. Formative assessment of pre-laboratory assignments ensures that students have demonstrated an ability to locate and interpret safety information and have planned their work so that they can act appropriately in the laboratory, while that of the notebook records ensures the correct production, recording and interpretation of data. Formative diagnostic assessment will also be provided by assessment of two preliminary pre-lab exercises which will be submitted and assessed and returned to the students prior to submission of the final versions of their reports. These ‘prototype’ submissions will constitute the basis of the formative assessment and help to ‘feed forward’ aspects that should be considered as students compose their final coursework write-ups.
To pass the module, students need to achieve a minimum aggregate mark of 40 %. There will also be an attendance requirement for the practical sessions. If the module is passed on reassessment, then the maximum mark awarded will be 40 %.
Core Text: Microscale Organic Laboratory, 5th edition, D. W. Mayo et al, Wiley, 2011.
Other Texts: The Organic Chem Lab Survival Manual, 8th edition, J. W. Zubrick, Wiley, 2011; Modern Organic Synthesis in the Laboratory, J. J. Li et al, OUP, 2007; Spectroscopic Methods in Organic Chemistry, 6th edition, Williams and Fleming, McGraw Hill, 2008.
Journals: Students will be directed to specific peer review articles.
Websites: www.rsc.org/learn-chemistry/interactive lab primer; Common Laboratory Techniques – https://chem.libretexts.org;