CY6053 - Advanced Organic Chemistry (2019/20)
|Module specification||Module approved to run in 2019/20|
|Module title||Advanced Organic Chemistry|
|Module level||Honours (06)|
|Credit rating for module||15|
|School||School of Human Sciences|
|Total study hours||150|
|Running in 2019/20||
Description: This module builds upon, and extends, material taught in the 2nd year, specifically in organic chemistry. It provides students with a deeper understanding of organic chemical reactivity.
Prior learning requirements
Organometallic catalysts in organic synthesis. LO2,LO5,LO6
Radical Chemistry. LO3,LO5
Asymmetric synthesis. LO1,LO5,LO6
Advanced approaches to synthesis. LO1,LO2,LO3,LO4,LO5,LO6
Determining the reaction mechanisms of chemical reactions. LO1,LO2,LO3,LO4,LO5,LO6
Balance of independent study and scheduled teaching activity
Acquisition of knowledge of the subject matter of this module will be promoted through lecturer-led sessions (19 hours) and tutorial workshops (8 hours); directed web-based learning and through the guided use of student-centred learning resources. Practical classes (12 hours) and tutorials will be used to consolidate and reflect on the material covered with guidance for directed activities. Self-managed time and private study (111 hours) should be spread out over the semester and not left until the final weeks. In addition, there will be weekly drop-in sessions, of one hour duration, which students can make use of in order to consolidate their understanding of the subject matter.
On successful completion of this module the student will be able to:
1. Demonstrate a detailed understanding of chemical reactivity and chemical mechanisms, both in organic and biological chemistry;
2. Understand the use of organometallic catalysts and in what contexts they are useful;
3. Describe the generation and reactivity of radicals in organic synthesis;
4. Understand and apply the principle of orthogonality in protecting group chemistry;
5. Critically analyse multistep syntheses for complex molecules, including stereochemical considerations, from simple, commercially available starting materials;
6. Compare and contrast similar chemical reactions as they occur biochemically and as they are carried out synthetically (Comparison of the biosynthesis of a complex natural product, with the synthetic procedures employed by organic chemists to make the same compound in the laboratory).
The module will be assessed by means of an end of module examination (50%, 1 hour) which will assess the students’ abilities to think critically and solve problems and by a coursework component (50%, 1000 words).
The coursework component will require completing the practical sessions and reporting the results in the style of a Journal article, which will also develop communication skills and engaging with the literature.
A minimum aggregate mark of 40% will be required to pass the module. If the module is passed on reassessment, then the maximum mark awarded will be 40%.
Core Text: Smith, M. B., March, J. (2013) March's Advanced Organic Chemistry: Reactions, Mechanisms, and Structure 7th Edition. Wiley
Other Texts: McMurry, J. E. (2016) Organic Chemistry 9th Edition. Brooks/Cole: Cengage learning
Vollhardt, P., Schore, N. (2014) Organic Chemistry: Structure and Function 7th Edition. Freeman
Clayden, J., Greeves, N., Warren, S. (2012) Organic Chemistry 2nd Edition. Oxford University Press
Parsons. A, F. (2000) An Introduction to Free Radical Chemistry. Wiley
Koskinen A. M. P. (2012) Asymmetric Synthesis of Natural Products 2nd Edition. Wiley
Dewick. P. M. (2009) Medicinal Natural Products: A Biosynthetic Approach 3rd Edition. Wiley
Websites: Specific links to websites will be given on Weblearn including links from www.khanacademy.org