module specification

Introduction to Cellular Pathology
This module provides an understanding and knowledge of the theory and practice of Cellular Pathology. This module surveys the incidence and cause of human diseases. Diseases are characterised by comparing pathological with non-pathological states, with particular reference to underlying molecular and cellular perturbations.  
Semester: Autumn, Spring, Summer (10 credit)

The aims of this module are aligned with the qualification descriptors within the Quality Assurance Agency’s Framework for Higher Education Qualifications. To provide, through in depth study, knowledge and understanding of the theory and practice of cellular pathology, provide a structural and functional description of the different cell and tissue types and survey the incidence and causes of major human disease and mortality.
Characterise molecular and cellular factors underpinning the pathogenesis of selected human diseases. It will also allow students to critically research and evaluate selected topics within the subject area, and communicate the results in a cogent and balanced manner, reinforce analytical, evaluative and communication skills. They will also research a topical issue in depth and present it at an appropriate level and reflect on the topics studied and their application in biomedical practice.

Fatal and non-fatal illness; the incidence and prevalence of disease; summary of UK mortality and morbidity statistics.
Mammalian cell phenotypes and normal tissue structure.  Cellular and tissue pathology. 
The pathological and non-pathological state: normal homeostasis v inadequate adaptation to changes in the internal and external environments. 
Mechanisms of disease processes and their associated molecular and cellular lesions: e.g. familial and congenital disease; pathogenic infection; immuno- and nutritional pathology; uncontrolled local and systemic responses to injury (trauma); modes of cell death; neoplasia, hyperplasia, hypertrophy; the effects of stress.  Primary, secondary and iatrogenic conditions; ageing processes and disease. Idiopathic states.
The use of a range of diagnostic techniques in the investigation of disease at a molecular and cellular level.  Quality systems.

Information pertaining to the subject matter will be presented through an integrated programme of lectures and supporting exercises, together with some use of a problem-based learning approach and the guided use of student-centred learning resources.  Lectures will be used to provide a conceptual framework.  Student centred assignments will enable students to reinforce and expand their knowledge, and develop subject specific skills and competence.

On successful completion of this module students will be able to:
1. Appreciate differences in the incidence of major diseases and in the causes of death and distinguish general causes of disease from pathogenesis and its functional effects.
2. Demonstrate an understanding of normal cell and tissue types, and describe how molecular and cellular lesions might lead to named disease states and show an understanding of diagnostic techniques and quality control in molecular and cellular pathology.
3. Research, evaluate, and discuss key issues within the subject area and communicate the results in a cogent and balanced manner.

The module will be formatively assessed by in-course online quizzes  (30%) and two coursework components. A reflective learning log (500 words)(30%) and a written assignment (40%; 2000 words). Criteria for assessment will include an understanding of the subject matter; an ability, both orally and written, to explain, describe and discuss the work; completeness and conciseness of written reports and essays with emphasis upon critical ability and scientific rigour. To pass the module students need to achieve a minimum aggregate mark of 50%.

Bancroft JD, Gamble M. (2007) Theory and Practice of Histological Techniques 6th Ed. Churchill Livingstone.
Damjanov I. (2006) Pathology for the Health Professions 3rd Ed. Elsevier.
Gould B. (2006) Pathophysiology for the Health Professions 3rd Ed. Saunders..
Kumar P, Clark M. (2005) Clinical Medicine 6th Ed. Saunders.
Kumar V, Abbas AK, Fausto N, Mitchell R. (2007)  Robbins' Basic Pathology 8th Ed. Saunders.
Phillips JD. (2007) The Biology of Disease. 2nd Ed. Blackwell.
Stevens A, Lowe J. (2005) Human Histology 3rd Ed. Elsevier Mosby.
Young B, Lowe JS, Stevens A, Heath JW. (2006) Wheater's Basic Histopathology 5th Ed. Churchill-Livingstone.