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module specification

BM7113 - Haemoglobinopathies (2023/24)

Module specification Module approved to run in 2023/24
Module title Haemoglobinopathies
Module level Masters (07)
Credit rating for module 10
School School of Human Sciences
Total study hours 100
0 hours Scheduled learning & teaching activities
100 hours Guided independent study
Assessment components
Type Weighting Qualifying mark Description
Other 20%   Online Quizzes
Coursework 30%   Reflective Learning Log - PLL (1000 words)
Coursework 50%   Written Assignment - ECA (1000 words)
Running in 2023/24

(Please note that module timeslots are subject to change)
Period Campus Day Time Module Leader
Year LMET Distance Learning Not applicable -

Module summary

This module provides an understanding and knowledge of the theory and practice of haematology. Examining the different elements that constitute blood in normal and diseased states, investigating the causes and diagnosis of anaemias, haemoglobinopathies and thalassaemias, haematological malignancy, haemostasis and thrombosis.

Prior learning requirements



This module provides an understanding and knowledge of the theory and practice of haemoglobinopathy screening, diagnosis and ethical issues arising. Aetiology, Epidemiology, Genetics and Pathophysiology of Haemoglobinopathies (focusing on Thalassaemia(Thal) and Sickle Cell (SC)) Counselling, management and treatment considerations. Categorisation of thalassemia’s, correlation of the results of laboratory testing with specific thalassaemias and haemoglobinopathies. 
Workshop: a) Case review and data analysis, SC and Beta Thal Major, antenatal and newborn screening, Laboratory diagnosis and interpretation exercises, - inexperienced NHS haematology staff and MSc Blood Science students.
OR b) Review of updates to laboratory handbook, Case review and data analysis, SC and Beta Thal Major, antenatal and newborn screening, ethical issues, New technologies (Mass Spectrometry, Capillary electrophoresis, other equipment as appropriate), Case study presentations, Unusual Haemoglobinopathies. – Experienced Haematology Staff.
OR c) Review of Haemoglobinopathies, recent updates, Newborn screening programme outcomes, antenatal and newborn screening, ethical issues, Blood Spot programme, Case study presentation and analysis. – newborn screening staff.

Learning Outcomes LO 1 - 3

Balance of independent study and scheduled teaching activity

Information pertaining to the subject matter will be presented through an integrated programme of lectures and supporting exercises, together with some use of a problem-based learning approach and the guided use of student-centred learning resources.  Lectures will be used to provide a conceptual framework.  Student centred assignments will enable students to reinforce and expand their knowledge, and develop subject specific skills and competence.

Learning outcomes

On successful completion of this module students will be able to:
1. Have knowledge of the laboratory processes for haemoglobinopathy screening and diagnosis nature, relate genetic theory to laboratory and clinical practice, including awareness of factors affecting prenatal diagnosis, antenatal/newborn screening processes, risks associated with the sample reagents, or method and other tests indicated by the outcome of the analysis and associated ethical issues. 
2. Understand principles of quality control, quality assurance, failsafe procedures, screening policies and diagnosis of haemoglobinopathies, and critically interpret and evaluate information case studies, reporting and communicating the results in the reflective learning log
3. Demonstrate through the reflective learning journal that the student has reflected on their own performance as an independent professional learner with a focus on their practice.

Assessment strategy

The module will be formatively assessed by in-course online quizzes and two coursework components. A reflective learning log (1000 words) and a written assignment (1000 words). Criteria for assessment will include an understanding of the subject matter; an ability, both orally and written, to explain, describe and discuss the work; completeness and conciseness of written reports and essays with emphasis upon critical ability and scientific rigour. To pass the module students need to achieve a minimum aggregate mark of 50%. There are no practical sessions.

Component                   Learning outcomes
Quizzes                                    1
Reflective learning log             1,2
Written assignment                 1,2,3


Bains B J. (2006) Haemoglobinopathy Diagnosis 2nd Ed. Blackwell.
Bain B J, Bates I. (2016) Dacie and Lewis Practical Haematology. Churchill Livingstone.
Daniel Y, Henthorn J. (2012) Sickle Cell and Thalassaemia – Handbook for laboratories 3rd Edn. NHS
Okpala I. (2008) Practical Management of Haemoglobinopathies. Wiley-Blackwell
Ryan K, Bain BJ, Worthington D, James J, Plews D, Mason A, Roper D, Rees DC, De La Salle B, Streetly A. (2010) Significant haemoglobinopathies: guidelines for screening and diagnosis.  BJH 149: 1; 35-49.  
Trent RJA. (2006) Diagnosis of Haemoglobiopathies, Clin Biochem Rev. 27:1; 27-38